HIV ile ya\u015fayan bir erkek hasta, karde\u015finden yap\u0131lan kemik ili\u011fi naklinin ard\u0131ndan hastal\u0131\u011f\u0131n etkilerinden i\u015flevsel olarak kurtuldu<\/p>\n\n\n\n
Norve\u00e7\u2019te 63 ya\u015f\u0131ndaki HIV pozitif bir hastan\u0131n, kemik ili\u011fi nakli sayesinde i\u015flevsel olarak hastal\u0131ktan kurtuldu\u011fu a\u00e7\u0131kland\u0131. Daha \u00f6nce de benzer vakalarda HIV remisyonu g\u00f6r\u00fclm\u00fc\u015f olsa da, bu sonucun ilk kez hastan\u0131n karde\u015finden yap\u0131lan ba\u011f\u0131\u015fla elde edilmesi dikkat \u00e7ekti.<\/p>\n\n\n\n
Scientific American\u2019da yer alan habere g\u00f6re, hastaya insan ba\u011f\u0131\u015f\u0131kl\u0131k yetmezli\u011fi vir\u00fcs\u00fcn\u00fcn en yayg\u0131n t\u00fcr\u00fc olan HIV-1\u2019e kar\u015f\u0131 diren\u00e7 sa\u011flayan nadir bir genetik mutasyona sahip karde\u015finden kemik ili\u011fi nakli yap\u0131ld\u0131. \u201cCCR5\u039432\u201d ad\u0131 verilen bu mutasyonun iki kopyas\u0131na sahip ki\u015filerde, HIV\u2019in h\u00fccrelere tutunmas\u0131n\u0131 sa\u011flayan CCR5 y\u00fczey proteini ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerinde (T h\u00fccreleri) \u00fcretilmiyor.Nature Microbiology\u2019de yay\u0131mlanan \u00e7al\u0131\u015fmaya g\u00f6re, nakil sonras\u0131nda don\u00f6r h\u00fccreler hastan\u0131n kemik ili\u011fini b\u00fcy\u00fck \u00f6l\u00e7\u00fcde devrald\u0131. V\u00fccuttaki t\u00fcm h\u00fccreler tamamen de\u011fi\u015fmemi\u015f olsa da, hastan\u0131n sa\u011fl\u0131kl\u0131 T h\u00fccre say\u0131s\u0131 bir y\u0131l i\u00e7inde h\u0131zla artt\u0131 ve iki y\u0131l sonra ART olarak bilinen tedaviyi b\u0131rakmas\u0131na ra\u011fmen sa\u011fl\u0131kl\u0131 seviyelerde kalmay\u0131 s\u00fcrd\u00fcrd\u00fc.ART tedavisi, HIV\u2019in v\u00fccutta \u00e7o\u011falmas\u0131n\u0131 ve ba\u015fkalar\u0131na bula\u015fmas\u0131n\u0131 engellese de vir\u00fcs\u00fc tamamen ortadan kald\u0131ram\u0131yor. Vir\u00fcs, \u201crezervuar\u201d olarak adland\u0131r\u0131lan gizli alanlarda varl\u0131\u011f\u0131n\u0131 s\u00fcrd\u00fcr\u00fcyor ve tedavi kesildi\u011finde yeniden aktif hale gelebiliyor. Ancak bu vakada, nakil sonras\u0131nda hastan\u0131n kan\u0131nda, ba\u011f\u0131rsak dokusunda ve kemik ili\u011finde HIV\u2019e rastlanmad\u0131.<\/p>\n\n\n\n
Buna kar\u015f\u0131n, bu tedavi y\u00f6ntemi HIV ile ya\u015fayan \u00e7o\u011fu ki\u015fi i\u00e7in uygulanabilir de\u011fil. Daha \u00f6nce New York, Londra ve D\u00fcsseldorf gibi merkezlerde benzer \u015fekilde iyile\u015fen hastalar, kemik ili\u011fi naklini genellikle kanser gibi ba\u015fka ciddi hastal\u0131klar nedeniyle almak zorunda kalm\u0131\u015ft\u0131.\u00c7al\u0131\u015fman\u0131n yazarlar\u0131ndan Jingmei Hsu, y\u00f6ntemin tek ba\u015f\u0131na HIV tedavisi i\u00e7in fazla riskli oldu\u011funa i\u015faret ederek, \u201cBu yakla\u015f\u0131m ancak ek hastal\u0131klar nedeniyle zaten nakil gereken hastalar i\u00e7in uygun\u201d de\u011ferlendirmesinde bulundu.Kemik ili\u011fi nakilleri; ciddi enfeksiyonlar, don\u00f6r h\u00fccrelerin al\u0131c\u0131n\u0131n v\u00fccuduna sald\u0131rmas\u0131 (GVHD) ve hatta \u00f6l\u00fcm gibi \u00f6nemli riskler bar\u0131nd\u0131r\u0131yor. Bu nedenle uzmanlar, bu y\u00f6ntemin ancak hastan\u0131n mevcut hastal\u0131\u011f\u0131n\u0131n riskinin daha y\u00fcksek oldu\u011fu durumlarda tercih edilmesi gerekti\u011fini vurguluyor.Ara\u015ft\u0131rmalar, baz\u0131 vakalarda don\u00f6r\u00fcn CCR5\u039432 mutasyonunun iki kopyas\u0131na sahip olmamas\u0131 durumunda bile HIV\u2019in remisyona girebildi\u011fini g\u00f6steriyor.\u00c7al\u0131\u015fmada don\u00f6r\u00fcn hastan\u0131n karde\u015fi olmas\u0131na vurgu yapan bilim insan\u0131 Bj\u00f6rn-Erik Ole Jensen, don\u00f6r ve al\u0131c\u0131 h\u00fccreleri aras\u0131ndaki benzerlik d\u00fczeyinin tedavi ba\u015far\u0131s\u0131n\u0131 etkileyebilece\u011fine dikkat \u00e7ekerek, \u201cKarde\u015ften yap\u0131lan nakiller \u00f6nemli bir fark yaratabilir; ancak h\u00e2l\u00e2 t\u00fcm mekanizmalar\u0131 tam olarak anlam\u0131\u015f de\u011filiz\u201d ifadelerini kulland\u0131.<\/p>\n\n\n\n
Kaynak: https:\/\/gazeteoksijen.com\/saglik\/kemik-iligi-nakli-ile-hivden-tamamen-kurtuldu-272199<\/p>\n\n\n\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
HIV ile ya\u015fayan bir erkek hasta, karde\u015finden yap\u0131lan kemik ili\u011fi naklinin ard\u0131ndan hastal\u0131\u011f\u0131n etkilerinden i\u015flevsel olarak kurtuldu Norve\u00e7\u2019te 63 ya\u015f\u0131ndaki HIV pozitif bir hastan\u0131n, kemik ili\u011fi nakli sayesinde i\u015flevsel olarak hastal\u0131ktan kurtuldu\u011fu a\u00e7\u0131kland\u0131. Daha \u00f6nce de benzer vakalarda HIV remisyonu g\u00f6r\u00fclm\u00fc\u015f olsa da, bu sonucun ilk kez hastan\u0131n karde\u015finden yap\u0131lan ba\u011f\u0131\u015fla elde edilmesi dikkat \u00e7ekti. […]<\/p>\n","protected":false},"author":2,"featured_media":5411,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-5410","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik"],"jetpack_featured_media_url":"https:\/\/gundexia.com\/wp-content\/uploads\/2026\/04\/1000108465.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/gundexia.com\/index.php?rest_route=\/wp\/v2\/posts\/5410","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gundexia.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gundexia.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gundexia.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/gundexia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5410"}],"version-history":[{"count":1,"href":"https:\/\/gundexia.com\/index.php?rest_route=\/wp\/v2\/posts\/5410\/revisions"}],"predecessor-version":[{"id":5412,"href":"https:\/\/gundexia.com\/index.php?rest_route=\/wp\/v2\/posts\/5410\/revisions\/5412"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gundexia.com\/index.php?rest_route=\/wp\/v2\/media\/5411"}],"wp:attachment":[{"href":"https:\/\/gundexia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5410"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gundexia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5410"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gundexia.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5410"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}